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The U.S. Food and Drug Administration has approved the use of Contrave (naltrexone hydrochloride and bupropion hydrochloride extended-release tablets) to help you manage chronic obesity in adults with a body mass index (BMI) greater than 27, provided that they also have problems with weight-related health issues such as Tupe2 diabestes, high cholesterol and/or hypertension (high blood pressure).Contrave can be a combination of two FDA-approved drugs, naltrexone and bupropion, in an extended-release formulation. Naltrexone qualifies to treat alcohol and opioid dependence. Bupropion is approved to treat depression and seasonal affective disorder so when an aid to stopping smoking treatment.'Obesity may be a major public health concern,' said Jean-Marc Guettier, M.D., director in the Division of Metabolism and Endocrinology Products in FDA's Center for Drug Evaluation and Research. 'When used as directed in combination with a healthy lifestyle that includes a reduced-calorie exercise and dieting, Contrave provides another treatment choice for chronic weight-loss for people who are obese or are overweight and also have at least one weight-related health problem.'The drug's effectiveness was evaluated in multiple many studies that included approximately 4,500 obese and overweight patients with and without significant weight-related conditions treated first year. All patients received lifestyle modification that was comprised of a reduced- calorie diet and regular physical activity. Results from a clinical study that enrolled patients without diabetes demonstrated that patients had an average weight loss of 4.1% as opposed to participants who have been given placebos) within a 12- month period, while another study involving patients with diabetes type 2 had a typical weight loss of 2% over treatment with placebo at 12 months.
Using two separate drugs to lose weight naturally can be very effective you can find combinations before the FDA now awaiting approval. When dealing with weight-loss and the individuals who go through it you need to err to the side of caution and let the FDA do its job and demand some study be done so the public recognizes the side effects and perils associated with the medications before we bring them. Keep in mind that drug companies will be in business to generate income and that they would say almost anything to keep people on his or her medications.
Researchers found out that participants investing in this drug for a year, dropped excess weight within four weeks and have kept the load off through the 56 weeks in the study. Contrave is a combination of the drugs naltrexone and bupropion, which appears to reflect a whole new trend of weight-loss drugs which are made up of several active ingredient, which may make them more effective and safer.
Combo-pilling may be the newest fad or even better the newest in the future under scrutiny and for that reason it is just more publicly known recently, comb-pilling for weight loss has been around since the eighties. The biggest reason that by using a combination of pills has become popular is the fact that as of right now there aren't any long term prescription weight loss supplements that have been licensed by the FDA besides orlistat. The truly disturbing part is doctors are prescribing these combinations of medications however some of the combinations are actually rejected or have yet to be authorized by the FDA.
Seizures are a side effect with Contrave and must not be taken in those with seizure disorders. The drug also can raise blood pressure and heart rate, and must not be used in people who have a history of heart attack or stroke in the earlier six months. Blood pressure and pulse should also be measured before beginning the drug and throughout therapy with the drug.
The FDA also warned that Contrave can raise blood pressure levels and heart rate and must not used in patients with uncontrolled high blood pressure level, along with by anyone with heart-related and cerebrovascular (circulatory dysfunction impacting the brain) disease. Patients using a history of cardiac arrest or stroke in the previous six months, life-threatening arrhythmias, or congestive heart failure were excluded through the clinical trials. Those taking Contrave must have their heart-rate and pulse monitored regularly. In addition, since the compound includes bupropion, Contrave comes with a boxed warning to alert physicians and patients on the increased chance of suicidal thoughts and behaviors associated with antidepressant drugs. The warning also notes that serious neuropsychiatric events have been reported in patients taking bupropion for stopping smoking.
The course of recovery, even for those utilizing the medications, centers read more about talk and less on pills because while drugs like acamprosate and naltrexone help change brain chemistry, they do not change minds. Once you take away the alcohol, sometimes with the successful using prescribed medicine, the minds still need work. Alcoholics who slip in recovery and non-alcoholics drink for fundamentally the same reason: It relieves social/physical/emotional tension. With alcoholics however, their bodies are programmed differently genetically and respond to drinking with an increase of drinking. So counseling or even a 12-step meeting helps those abstinent keep from using the first drink. Recovery has little or no to do with stopping the drinking and people successful in recovery admit they're success is founded on learning or relearning the best way to manage life's tensions.
